REDOX DRIVEN B12-LIGAND SWITCH DRIVES CARH PHOTORESPONSE

Redox driven B12-ligand switch drives CarH photoresponse

Abstract CarH is a coenzyme B12-dependent photoreceptor involved in regulating carotenoid biosynthesis.How light-triggered cleavage of the B12 Co-C bond culminates in CarH tetramer dissociation to initiate transcription remains unclear.Here, a spindle series of crystal structures of the CarH B12-binding domain after illumination suggest formation o

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Multi-level predictors of psychological problems among methadone maintenance treatment patients in difference types of settings in Vietnam

Abstract Background Methadone, a long-acting opioid agonist maintenance treatment (MMT) is used to treat opioid addiction by preventing opioid withdrawal and reducing cravings.However, it is important to note that mental conditions may persist, or even remain undetected while methadone maintenance treatment is ongoing.This study aimed to examine th

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